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KMID : 1149220030110020173
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Korean Journal of Oriental Medical Prescription
2003 Volume.11 No. 2 p.173 ~ p.184
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The Effects of Salviae miltiorrhizae Radix, Carthami Flos on Brain Ischemia Experimentally Induced from the Occlusion of Left Common Carotid Artery in Rats
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Kim Bang-Oul
Kim Jeong-Sang
Kim Kyung-Su
Jeon Sang-Yoon
Hong Seok
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Abstract
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Objectives: This study investigates the effects of Salviae miltiorrhizae Radix, Carthami Flos on Brain ischemia of the rats induced from the Occlusion of Lt. Common Carotid Artery.
Methods: I observed effects using light microscopes and examined tissue of parietal lobe and hippocampus and VEGF-immunoreactive cells.
Results: A small number of VEGF-immunoreactive cells are observed in the control group. VEGF-immunoreactive cells in Salviae miltiorrhizae Radix-administered group were slightly increased compared with control group. VEGF-immunoreactive cells in Carthami Flos-administered group were significantly increased compared with control group. Neurons of parietal lobe and pyramidal cells of hippocampus in the control group were greatly damaged.(neuronal densitity, form of dendrite and axon) On the other hand, neurons of parietal lobe and pyramidal cells of hippocampus in Salviae miltiorrhizae Radix-administered group were less damaged. Neurons of parietal lobe and pyramidal cells of hippocampus in Carthami Flos-administered group were significantly less damaged compared with control group.
Conclusion : Salviae miltiorrhizae Radix, Carthami Flos can effect on stimulating angiogenesis and reducinging the damage of neurons in the rats induced from the Occlusion of Lt. Common Carotid Artery.
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KEYWORD
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Brain ischemia, Salviae miltiorrhizae Radix, Carthami Flos
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